[Composition and biological activity of triterpenes and steroids from Inonotus obliquus (chaga)].

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Citation abstract

Data on the chemical composition of triterpenic and steroid compounds, isolated from the chaga mushroom grown in natural environment or in a synthetic culture have been summarized. Special attention has been paid to the biological activity of chaga mushroom extracts and these particular compounds against various cancer cell lines in vitro and in vivo. This analysis has demonstrated some common features in inhibition of growth of various cell lines by chaga mushroom components. In this context, the most active are triterpene compounds containing OH group at C-22 and a side chain unsaturated bond.

Sistematizirovany dannye po khimicheskomu sostavu veshchestv triterpenovoĭ i steroidnoĭ prirody, vydelennykh iz chagi, kak vyrashchennoĭ v usloviiakh iskusstvennoĭ kul'tury, tak i proizrastaiushcheĭ v prirode. Privedeny svedeniia po biologicheskoĭ aktivnosti ékstraktov iz chagi i étikh soedineniĭ v otnoshenii razlichnykh liniĭ kletok raka in vitro i in vivo. Provedennyĭ analiz pozvolil vyiavit' opredelennye zakonomernosti v éffektivnosti podavleniia rosta razlichnykh liniĭ kletok. Ustanovleno, chto naibol'sheĭ aktivnost'iu obladaiut triterpenovye soedineniia, soderzhashchie ON-gruppu pri S-22 i nenasyshchennuiu sviaz' v bokovoĭ tsepi.