Structural Characterization and Anti-Inflammatory Activities of Polysaccharide From Hericium erinaceus Mycelium.

Hericium erinaceus

Immune supportCognition & nerves

SpeciesLion's Mane, Yamabushitake

JournalBiotechnology and applied biochemistry

Year2026

Key points

A novel heteropolysaccharide named HEP-S was separated from the mycelium of Hericium erinaceus using hot water extraction
The structure of HEP-S (2.45 × 10 6 Da) is mainly composed of →4,6)-α-D-Glcp(1→, →2)-α-D-Manp(1→, →4)-α-D-Glcp(1→, →3,6)-β-D-Glcp(1→, T-β-D-Galp(1→, and →4)-β-D-Galp(1→. In addition, we investigated the anti-inflammatory activity and mechanism of HEP-S in lipopolysaccharide-stimulated RAW264.7 cells
HEP-S (20, 40, and 80 µg/mL) could suppress the production of inflammatory cytokines by reducing vital transcription factors in the nuclear factor-κB signaling (NF-κB) pathway
The results showed that HEP-S exhibited notable anti-inflammatory activity on RAW 264.7, demonstrating its potential therapeutic effect on relieving gastritis

Metadata-grounded summary

Citation abstract

A novel heteropolysaccharide named HEP-S was separated from the mycelium of Hericium erinaceus using hot water extraction. The structure of HEP-S (2.45 × 10 6 Da) is mainly composed of →4,6)-α-D-Glcp(1→, →2)-α-D-Manp(1→, →4)-α-D-Glcp(1→, →3,6)-β-D-Glcp(1→, T-β-D-Galp(1→, and →4)-β-D-Galp(1→. In addition, we investigated the anti-inflammatory activity and mechanism of HEP-S in lipopolysaccharide-stimulated RAW264.7 cells. HEP-S (20, 40, and 80 µg/mL) could suppress the production of inflammatory cytokines by reducing vital transcription factors in the nuclear factor-κB signaling (NF-κB) pathway. The results showed that HEP-S exhibited notable anti-inflammatory activity on RAW 264.7, demonstrating its potential therapeutic effect on relieving gastritis.

Citation

Sun C, Wang L, Shi Y, Geng X, Sun H, Li T, et al. (2026). Structural Characterization and Anti-Inflammatory Activities of Polysaccharide From Hericium erinaceus Mycelium. Biotechnology and applied biochemistry https://doi.org/10.1002/bab.70148 PMID: 42027032

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