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Enoki, Winter Mushroom · 2002 · Research Support, Non U.S. Gov'T

Low relevance

Mushroom-derived preparations in the prevention of H2O2-induced oxidative damage to cellular DNA.

Flammulina velutipes

Immune support
SpeciesEnoki, Winter Mushroom
JournalTeratogenesis, carcinogenesis, and mutagenesis
Year2002

Key points

  • Aqueous extracts of the sporophores of eight mushroom species were assessed for their ability to prevent H2O2-induced oxidative damage to cellular DNA using the single-cell gel electrophoresis ("Comet") assay
  • The highest genoprotective effects were obtained with cold (20 degrees C) and hot (100 degrees C) water extracts of Agaricus bisporus and Ganoderma lucidum fruit bodies, respectively
  • No protective effects were observed with Mushroom Derived Preparations (MDPs) from Flammulina velutipes, Auricularia auricula, Hypsizygus marmoreus, Lentinula edodes, Pleurotus sajor-caju, and Volvariella volvacea
  • These findings indicate that some edible mushrooms represent a valuable source of biologically active compounds with potential for protecting cellular DNA from oxidative damage

Metadata-grounded summary

Citation abstract

Aqueous extracts of the sporophores of eight mushroom species were assessed for their ability to prevent H2O2-induced oxidative damage to cellular DNA using the single-cell gel electrophoresis ("Comet") assay. The highest genoprotective effects were obtained with cold (20 degrees C) and hot (100 degrees C) water extracts of Agaricus bisporus and Ganoderma lucidum fruit bodies, respectively. No protective effects were observed with Mushroom Derived Preparations (MDPs) from Flammulina velutipes, Auricularia auricula, Hypsizygus marmoreus, Lentinula edodes, Pleurotus sajor-caju, and Volvariella volvacea. These findings indicate that some edible mushrooms represent a valuable source of biologically active compounds with potential for protecting cellular DNA from oxidative damage.

Citation

Shi YL, James AE, Benzie IF, Buswell JA (2002). Mushroom-derived preparations in the prevention of H2O2-induced oxidative damage to cellular DNA. Teratogenesis, carcinogenesis, and mutagenesis https://doi.org/10.1002/tcm.10008 PMID: 11835288

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