Effects of Flammulina velutipes polysaccharides on gut microbiota composition and metabolism in vitro fermentation.

Flammulina velutipes

Immune supportGut & microbiome

SpeciesEnoki, Winter Mushroom

JournalFood science and biotechnology

Year2023

Key points

UNLABELLED: Flammulina velutipes polysaccharides (FVP) exhibit many biological activities, but the effects on gut microflora and metabolism were still unclear
In addition, 16S rRNA sequencing were used to assess the effects of FVP on the gut microbiota
The results showed that FVP was mainly consisted of glucose, mannose, xylose, fucose and galactose
FVP is shown to increase the relative abundances of Bifidobacteriaceae, as well as Bacteroidaceae and remarkably decrease the numbers of genera Lachnospiraceae coupled with Enterococcaceae
The differential metabolites were identified and mainly involved the metabolism of glycerophospholipid, linoleic acid and synthesis of unsaturated fatty acids
SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10068-022-01192-y

Metadata-grounded summary

Citation abstract

UNLABELLED: Flammulina velutipes polysaccharides (FVP) exhibit many biological activities, but the effects on gut microflora and metabolism were still unclear. Here, we explored the composition of FVP, their influence on human gut microflora composition and metabolites. FVP were used to vitro fermentation through human fecal inoculums. In addition, 16S rRNA sequencing were used to assess the effects of FVP on the gut microbiota. The metabolic profiles were investigated using untargeted metabolomics approaches in the LC-MS platform. The results showed that FVP was mainly consisted of glucose, mannose, xylose, fucose and galactose. FVP is shown to increase the relative abundances of Bifidobacteriaceae, as well as Bacteroidaceae and remarkably decrease the numbers of genera Lachnospiraceae coupled with Enterococcaceae. The differential metabolites were identified and mainly involved the metabolism of glycerophospholipid, linoleic acid and synthesis of unsaturated fatty acids. FVP may exhibit biological activity function by regulating gut microflora composition and metabolites.

SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10068-022-01192-y.

Citation

Su A, Ma G, Ma N, Pei F, Yang W, Hu Q (2023). Effects of Flammulina velutipes polysaccharides on gut microbiota composition and metabolism in vitro fermentation. Food science and biotechnology https://doi.org/10.1007/s10068-022-01192-y PMID: 36778094

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