Back to search

Turkey Tail, Yun Zhi · 2018 · Brief Report

Low relevance

Mushroom extract inhibits ultraviolet B-induced cellular senescence in human keratinocytes.

Trametes versicolor

OncologyImmune support
SpeciesTurkey Tail, Yun Zhi
JournalCytotechnology
Year2018

Key points

  • Mushrooms possess various bioactivities and are used as nutritional supplements and medicinal products
  • Twenty-nine bioactive components have been extracted recently from mushrooms grown in Nepal
  • In this study, we evaluated the ability of these mushroom extracts to augment SIRT1, a mammalian SIR2 homologue localized in cytosol and nuclei
  • We established a system for screening food ingredients that augment the SIRT1 promoter in HaCaT cells, and identified a SIRT1-augmenting mushroom extract (number 28, Trametes versicolor)
  • UVB irradiation induced cellular senescence in HaCaT cells, as evidenced by increased activity and expression of cellular senescence markers including senescence-associated β-galactosidase, p21, p16, phosphorylated p38, and γH2AX. Results clearly showed that the mushroom extract (No. 28) suppressed the ultraviolet B irradiation-induced cellular senescence in HaCaT cells possibly through augmenting SIRT1 expression

Metadata-grounded summary

Citation abstract

Mushrooms possess various bioactivities and are used as nutritional supplements and medicinal products. Twenty-nine bioactive components have been extracted recently from mushrooms grown in Nepal. In this study, we evaluated the ability of these mushroom extracts to augment SIRT1, a mammalian SIR2 homologue localized in cytosol and nuclei. We established a system for screening food ingredients that augment the SIRT1 promoter in HaCaT cells, and identified a SIRT1-augmenting mushroom extract (number 28, Trametes versicolor). UVB irradiation induced cellular senescence in HaCaT cells, as evidenced by increased activity and expression of cellular senescence markers including senescence-associated β-galactosidase, p21, p16, phosphorylated p38, and γH2AX. Results clearly showed that the mushroom extract (No. 28) suppressed the ultraviolet B irradiation-induced cellular senescence in HaCaT cells possibly through augmenting SIRT1 expression.

Citation

Chong Z, Matsuo H, Kuroda M, Yamashita S, Parajuli GP, Manandhar HK, et al. (2018). Mushroom extract inhibits ultraviolet B-induced cellular senescence in human keratinocytes. Cytotechnology https://doi.org/10.1007/s10616-018-0229-1 PMID: 29860669

Open citation