Agarikon, Quinine Conk · 2018 · Journal Article
High relevanceLanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity.
Fomitopsis officinalis
Key points
- Fomitopsis officinalis is a medicinal fungus, known as 'Agarikon', and is used traditionally in the treatment of asthma and rheumatism in Mongolia
- The investigation of the chemical constituents of F. officinalis led to the isolation of 4 new lanostane triterpenoids together with 4 known triterpenoids
- Inhibitory activity against Trypanosoma congolense, which causes fatal diseases in animals including livestock, was estimated for the isolated compounds
- Compounds 2-5 and 8 exhibited moderate inhibition activities with IC 50 values ranging from 7.0-27.1 µM
Metadata-grounded summary
Citation abstract
Fomitopsis officinalis is a medicinal fungus, known as 'Agarikon', and is used traditionally in the treatment of asthma and rheumatism in Mongolia. The investigation of the chemical constituents of F. officinalis led to the isolation of 4 new lanostane triterpenoids together with 4 known triterpenoids. Inhibitory activity against Trypanosoma congolense, which causes fatal diseases in animals including livestock, was estimated for the isolated compounds. Compounds 2-5 and 8 exhibited moderate inhibition activities with IC 50 values ranging from 7.0-27.1 µM.
Citation
Naranmandakh S, Murata T, Odonbayar B, Suganuma K, Batkhuu J, Sasaki K (2018). Lanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity. Journal of natural medicines https://doi.org/10.1007/s11418-018-1182-1 PMID: 29417466
Open citation