Strophasterols E and F: Rearranged ergostane-type sterols from Pleurotus eryngii.

Pleurotus eryngii

Gut & microbiomeLiver support

SpeciesKing Oyster, Eryngii

JournalBioorganic chemistry

Year2019

Key points

Strophasterols E (1) and F (2) were isolated from the fruiting bodies of Pleurotus eryngii, together with four new ergostane-type sterols (3-6)
Single-crystal X-ray diffraction analysis performed on the tris-p-bromobenzoate derivatives of compounds 1 and 2 allowed these two compounds to be identified as the structurally rare (22S,23R)- and (22S,23S)-5α,6α-epoxy-3β,7β,23-trihydroxy-15(14 → 22)-abeo-ergost-8-en-14-one, respectively
The inhibitory effects on nitric oxide production of the six new steroids thus isolated from the fruiting bodies of P. eryngii were also evaluated

Metadata-grounded summary

Citation abstract

Strophasterols E (1) and F (2) were isolated from the fruiting bodies of Pleurotus eryngii, together with four new ergostane-type sterols (3-6). Single-crystal X-ray diffraction analysis performed on the tris-p-bromobenzoate derivatives of compounds 1 and 2 allowed these two compounds to be identified as the structurally rare (22S,23R)- and (22S,23S)-5α,6α-epoxy-3β,7β,23-trihydroxy-15(14 → 22)-abeo-ergost-8-en-14-one, respectively. The inhibitory effects on nitric oxide production of the six new steroids thus isolated from the fruiting bodies of P. eryngii were also evaluated.

Citation

Kikuchi T, Isobe M, Uno S, In Y, Zhang J, Yamada T (2019). Strophasterols E and F: Rearranged ergostane-type sterols from Pleurotus eryngii. Bioorganic chemistry https://doi.org/10.1016/j.bioorg.2019.103011 PMID: 31154097

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