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Chaga · 2020 · Research Support, Non U.S. Gov'T

High relevance

Modified lanostane-type triterpenoids with neuroprotective effects from the fungus Inonotus obliquus.

Inonotus obliquus

Cognition & nervesMetabolic healthSkin & hydration
SpeciesChaga
JournalBioorganic chemistry
Year2020

Key points

  • Six undescribed lanostane triterpenoids (1-6), together with three known compounds (7-9) were isolated from Inonotus obliquus
  • Compounds 3-5 are the rare natural compounds featuring a 4,5-seco-lanostane core with a 5,7,9-trien-21,24-cyclopentane moiety
  • The structure elucidation of the compounds was conducted by spectroscopic techniques and the ECD method
  • The absolute configuration of compound 1 was confirmed by single-crystal X-ray diffraction analysis
  • All isolated compounds were assayed for their neuroprotective activity against H 2 O 2 -induced cell injury using human neuroblastoma SH-SY5Y cells
  • Compound 9 exhibited the most potent neuroprotective activity and the flow cytometry analysis indicated that 9 could protect SH-SY5Y cells from oxidative damage by inhibiting cell apoptosis

Metadata-grounded summary

Citation abstract

Six undescribed lanostane triterpenoids (1-6), together with three known compounds (7-9) were isolated from Inonotus obliquus. Compounds 3-5 are the rare natural compounds featuring a 4,5-seco-lanostane core with a 5,7,9-trien-21,24-cyclopentane moiety. The structure elucidation of the compounds was conducted by spectroscopic techniques and the ECD method. The absolute configuration of compound 1 was confirmed by single-crystal X-ray diffraction analysis. All isolated compounds were assayed for their neuroprotective activity against H 2 O 2 -induced cell injury using human neuroblastoma SH-SY5Y cells. Compound 9 exhibited the most potent neuroprotective activity and the flow cytometry analysis indicated that 9 could protect SH-SY5Y cells from oxidative damage by inhibiting cell apoptosis.

Citation

Zou CX, Dong SH, Hou ZL, Yao GD, Lin B, Huang XX, et al. (2020). Modified lanostane-type triterpenoids with neuroprotective effects from the fungus Inonotus obliquus. Bioorganic chemistry https://doi.org/10.1016/j.bioorg.2020.104438 PMID: 33171406

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