Mesima, Sanghwang · 2011 · Research Support, Non U.S. Gov'T
Medium relevancePhellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus.
Phellinus linteus
Oncology
Key points
- A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis
- Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC(50) of 6 μM and also showed antibacterial activity against S. aureus and MRSA
Metadata-grounded summary
Citation abstract
A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC(50) of 6 μM and also showed antibacterial activity against S. aureus and MRSA.
Citation
Cho JY, Kwon YJ, Sohn MJ, Seok SJ, Kim WG (2011). Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus. Bioorganic & medicinal chemistry letters https://doi.org/10.1016/j.bmcl.2011.01.080 PMID: 21316961
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