Turkey Tail, Yun Zhi · 2015 · Research Support, Non U.S. Gov'T
Low relevanceQuantitative structure-activity relationship of antifungal activity of rosin derivatives.
Trametes versicolor
Key points
- To develop new rosin-based wood preservatives with good antifungal activity, 24 rosin derivatives were synthesized, bioassay tested with Trametes versicolor and Gloeophyllum trabeum, and subjected to analysis of their quantitative structure-activity relationships (QSAR)
- A QSAR analysis using Ampac 9.2.1 and Codessa 2.7.16 software built two QSAR models of antifungal ratio for T. versicolor and G. trabeum with values of R(2)=0.9740 and 0.9692, respectively
- Based on the models, tri-N-(3-hydroabietoxy-2-hydroxy) propyl-triethyl ammonium chloride was designed and the bioassay test result proved its better inhibitory effect against the two selected fungi as expected
Metadata-grounded summary
Citation abstract
To develop new rosin-based wood preservatives with good antifungal activity, 24 rosin derivatives were synthesized, bioassay tested with Trametes versicolor and Gloeophyllum trabeum, and subjected to analysis of their quantitative structure-activity relationships (QSAR). A QSAR analysis using Ampac 9.2.1 and Codessa 2.7.16 software built two QSAR models of antifungal ratio for T. versicolor and G. trabeum with values of R(2)=0.9740 and 0.9692, respectively. Based on the models, tri-N-(3-hydroabietoxy-2-hydroxy) propyl-triethyl ammonium chloride was designed and the bioassay test result proved its better inhibitory effect against the two selected fungi as expected.
Citation
Wang H, Nguyen TT, Li S, Liang T, Zhang Y, Li J (2015). Quantitative structure-activity relationship of antifungal activity of rosin derivatives. Bioorganic & medicinal chemistry letters https://doi.org/10.1016/j.bmcl.2014.11.034 PMID: 25466709
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