Lion's Mane, Yamabushitake · 2015 · Research Support, Non U.S. Gov'T
Medium relevanceA new cerebroside from the fruiting bodies of Hericium erinaceus and its applicability to cancer treatment.
Hericium erinaceus
Key points
- A new cerebroside, cerebroside E (1) was isolated from the fruiting bodies of Hericium erinaceus (Hericiaceae)
- The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR, HR-MS, and chemical reactions
- Compound 1 was evaluated for its applicability to medicinal use in several human diseases using cell-based assays
- As a result, compound 1 attenuated cisplatin-induced nephrotoxicity in LLC-PK1 cells and exhibited a significant inhibitory effect on angiogenesis in HUVECs
- These results collectively reflect the beneficial effects of compound 1 in cancer treatment
Metadata-grounded summary
Citation abstract
A new cerebroside, cerebroside E (1) was isolated from the fruiting bodies of Hericium erinaceus (Hericiaceae). The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR, HR-MS, and chemical reactions. Compound 1 was evaluated for its applicability to medicinal use in several human diseases using cell-based assays. As a result, compound 1 attenuated cisplatin-induced nephrotoxicity in LLC-PK1 cells and exhibited a significant inhibitory effect on angiogenesis in HUVECs. These results collectively reflect the beneficial effects of compound 1 in cancer treatment.
Citation
Lee SR, Jung K, Noh HJ, Park YJ, Lee HL, Lee KR, et al. (2015). A new cerebroside from the fruiting bodies of Hericium erinaceus and its applicability to cancer treatment. Bioorganic & medicinal chemistry letters https://doi.org/10.1016/j.bmcl.2015.10.092 PMID: 26547693
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