Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus.

Inonotus obliquus

OncologyImmune supportMetabolic healthSkin & hydration

SpeciesChaga

JournalCarbohydrate polymers

Year2012

Key points

The medicinal mushroom Inonotus obliquus has been used as a folk remedy for a long time in Russia and East-European countries to treat gastrointestinal cancer, cardiovascular disease and diabetes
In our study, a water-soluble polysaccharide (ISP2a) was successfully purified from I. obliquus by DEAE-Sepharose CL-6B and Sepharose CL-6B column chromatography
In vivo ISP2a had not only shown antitumor activity, but also could significantly enhance the immune response of tumor-bearing mice
In addition, ISP2a significantly enhanced the lymphocyte proliferation and increased the production of TNF-α. Results of these studies demonstrated that ISP2a had a potential application as natural antitumor agent with immunomodulatory activity

Metadata-grounded summary

Citation abstract

The medicinal mushroom Inonotus obliquus has been used as a folk remedy for a long time in Russia and East-European countries to treat gastrointestinal cancer, cardiovascular disease and diabetes. In our study, a water-soluble polysaccharide (ISP2a) was successfully purified from I. obliquus by DEAE-Sepharose CL-6B and Sepharose CL-6B column chromatography. In vivo ISP2a had not only shown antitumor activity, but also could significantly enhance the immune response of tumor-bearing mice. In addition, ISP2a significantly enhanced the lymphocyte proliferation and increased the production of TNF-α. Results of these studies demonstrated that ISP2a had a potential application as natural antitumor agent with immunomodulatory activity.

Citation

Fan L, Ding S, Ai L, Deng K (2012). Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus. Carbohydrate polymers https://doi.org/10.1016/j.carbpol.2012.06.013 PMID: 22840014

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