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Cordyceps, Scarlet Club · 2015 · Research Support, Non U.S. Gov'T

High relevance

Antihyperlipidemic and hepatoprotective activities of residue polysaccharide from Cordyceps militaris SU-12.

Cordyceps militaris

Immune supportMetabolic healthLiver support
SpeciesCordyceps, Scarlet Club
JournalCarbohydrate polymers
Year2015

Key points

  • Cordyceps militaris has been artificially cultivated in China, and the great amounts of produced medium residue were discarded after the harvest
  • The aims of this work were to analyze the structure of the residue polysaccharide (RPS) of C. militaris SU-12, and to investigate the pharmacological effects of RPS on lipid metabolism and oxidative stress
  • RPS was composed of glucose, arabinose and mannose with a ratio of 62:1.6:1 by gas chromatography analysis, and the Mw (weight-average molecular weight), Mn (number-average molecular weight) and Mz (z-average molecular weight) of RPS were 2.86×10(3), 6.85×10(2), and 1.97×10(4)Da, respectively
  • The mice experiments demonstrated that RPS could reduce the levels of blood and liver lipid, and improve the glutamate pyruvate transaminase and antioxidant activity
  • The histopathological observations of mice livers indicated that RPS could attenuate liver cell injury
  • Results suggest that the RPS might be used as a potential antihyperlipidemic, hepatoprotective and antioxidant product

From the paper

Abstract

Cordyceps militaris has been artificially cultivated in China, and the great amounts of produced medium residue were discarded after the harvest. The aims of this work were to analyze the structure of the residue polysaccharide (RPS) of C. militaris SU-12, and to investigate the pharmacological effects of RPS on lipid metabolism and oxidative stress. RPS was composed of glucose, arabinose and mannose with a ratio of 62:1.6:1 by gas chromatography analysis, and the Mw (weight-average molecular weight), Mn (number-average molecular weight) and Mz (z-average molecular weight) of RPS were 2.86×10(3), 6.85×10(2), and 1.97×10(4)Da, respectively. The mice experiments demonstrated that RPS could reduce the levels of blood and liver lipid, and improve the glutamate pyruvate transaminase and antioxidant activity. The histopathological observations of mice livers indicated that RPS could attenuate liver cell injury. Results suggest that the RPS might be used as a potential antihyperlipidemic, hepatoprotective and antioxidant product.

Citation

Wang L, Xu N, Zhang J, Zhao H, Lin L, Jia S, et al. (2015). Antihyperlipidemic and hepatoprotective activities of residue polysaccharide from Cordyceps militaris SU-12. Carbohydrate polymers https://doi.org/10.1016/j.carbpol.2015.06.016 PMID: 26256194

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