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Snow Fungus, Silver Ear · 2022 · Review

Medium relevance

Insight on updates in polysaccharides for ocular drug delivery.

Tremella fuciformis

Immune supportGut & microbiomeLiver supportSkin & hydration
SpeciesSnow Fungus, Silver Ear
JournalCarbohydrate polymers
Year2022

Key points

  • Ocular drug delivery is a significantly challenging task due to the presence of various anatomical and physiological barriers in the eye
  • Naturally available polysaccharides, when used as drug vehicles provide increased retention time, bioavailability, and penetration due to their unique mucoadhesive and charge-possessing nature
  • This review discusses the polysaccharide-based drug delivery system for the eye
  • Polysaccharides like alginic acid, cellulose derivatives, chitosan, pectin, xanthan gum, gellan gum, and hyaluronic acid are reviewed in this report
  • Additionally, emphasis is given to some of the recently investigated polymers such as sugarcane bagasse cellulose, a polysaccharide extracted from the seeds of Manilkara zapota, and Tremella fuciformis polysaccharide as drug vehicles for effective ocular drug delivery
  • This review also provides insight on clinical status and FDA-approved polysaccharides for ophthalmic delivery of therapeutics

Metadata-grounded summary

Citation abstract

Ocular drug delivery is a significantly challenging task due to the presence of various anatomical and physiological barriers in the eye. Naturally available polysaccharides, when used as drug vehicles provide increased retention time, bioavailability, and penetration due to their unique mucoadhesive and charge-possessing nature. This review discusses the polysaccharide-based drug delivery system for the eye. Polysaccharides like alginic acid, cellulose derivatives, chitosan, pectin, xanthan gum, gellan gum, and hyaluronic acid are reviewed in this report. Additionally, emphasis is given to some of the recently investigated polymers such as sugarcane bagasse cellulose, a polysaccharide extracted from the seeds of Manilkara zapota, and Tremella fuciformis polysaccharide as drug vehicles for effective ocular drug delivery. This review also provides insight on clinical status and FDA-approved polysaccharides for ophthalmic delivery of therapeutics.

Citation

Chandra NS, Gorantla S, Priya S, Singhvi G (2022). Insight on updates in polysaccharides for ocular drug delivery. Carbohydrate polymers https://doi.org/10.1016/j.carbpol.2022.120014 PMID: 36184137

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