New isoindolinones from the fruiting bodies of Hericium erinaceum.

Hericium erinaceus

Cognition & nerves

SpeciesLion's Mane, Yamabushitake

JournalFitoterapia

Year2016

Key points

Hericium erinaceus is a well-known medicinal and edible mushroom, which is considered as a potential source to obtain antitumor candidates
In this work, five new isoindolinones, named erinaceolactams A-E (1-5), along with five known compounds (6-10), were isolated from 70% ethanol extract of the fruiting bodies of H. erinaceus
The structures of new compounds were validated by HRESIMS and 1D, 2D NMR. It's worth mentioning that there are two pairs of isomers included in the new compounds
Moreover, their cytotoxicity against metastatic human hepatocellular carcinoma cell lines SMMC-7221 and MHCC-97H were evaluated
The results showed that compounds 6 and 7 exhibited promising inhibitory potency against the growth of two cell lines

Metadata-grounded summary

Citation abstract

Hericium erinaceus is a well-known medicinal and edible mushroom, which is considered as a potential source to obtain antitumor candidates. In this work, five new isoindolinones, named erinaceolactams A-E (1-5), along with five known compounds (6-10), were isolated from 70% ethanol extract of the fruiting bodies of H. erinaceus. The structures of new compounds were validated by HRESIMS and 1D, 2D NMR. It's worth mentioning that there are two pairs of isomers included in the new compounds. Moreover, their cytotoxicity against metastatic human hepatocellular carcinoma cell lines SMMC-7221 and MHCC-97H were evaluated. The results showed that compounds 6 and 7 exhibited promising inhibitory potency against the growth of two cell lines.

Citation

Wang XL, Xu KP, Long HP, Zou H, Cao XZ, Zhang K, et al. (2016). New isoindolinones from the fruiting bodies of Hericium erinaceum. Fitoterapia https://doi.org/10.1016/j.fitote.2016.04.010 PMID: 27094113

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