Secondary metabolites from the Cordyceps-colonizing fungus Aspergillus versicolor ZJUTE2.

Cordyceps militaris

Energy & fatigueGut & microbiome

SpeciesCordyceps, Scarlet Club

JournalFitoterapia

Year2023

Key points

Two new polyketides versicolorones A-B (1-2), one new diketopiperazine derivative aspergiamide B methyl ester (3), along with twenty known compounds 4-23, were obtained from the EtOAc extract of the Cordyceps-colonizing fungus Aspergillus versicolor ZJUTE2
The structures of 1-3 were established by detailed interpretation of the spectroscopic data and their absolute configurations were established by comparative analyses of the calculated and experimental ECD spectra
In the in-vitro bioassay, compounds 8 and 21 exhibited significant inhibitory activity against the Escherichia coli β-glucuronidase (EcGUS) with IC 50 values of 54.73 ± 2.69 and 56.59 ± 1.77 μM, respectively

Metadata-grounded summary

Citation abstract

Two new polyketides versicolorones A-B (1-2), one new diketopiperazine derivative aspergiamide B methyl ester (3), along with twenty known compounds 4-23, were obtained from the EtOAc extract of the Cordyceps-colonizing fungus Aspergillus versicolor ZJUTE2. The structures of 1-3 were established by detailed interpretation of the spectroscopic data and their absolute configurations were established by comparative analyses of the calculated and experimental ECD spectra. In the in-vitro bioassay, compounds 8 and 21 exhibited significant inhibitory activity against the Escherichia coli β-glucuronidase (EcGUS) with IC 50 values of 54.73 ± 2.69 and 56.59 ± 1.77 μM, respectively.

Citation

Ran K, Fu Z, Wu M, Chen X, Xu S, Tong C, et al. (2023). Secondary metabolites from the Cordyceps-colonizing fungus Aspergillus versicolor ZJUTE2. Fitoterapia https://doi.org/10.1016/j.fitote.2023.105501 PMID: 37028494

Open citation