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Reishi, Lingzhi · 2025 · Journal Article

Medium relevance

One new polyketide and four new sesquiterpenes derivatives from the fungicolous fungi aspergillus nidulans LZ8 of Ganoderma lingzhi.

Ganoderma lucidum

OncologyImmune supportMetabolic healthLiver support
SpeciesReishi, Lingzhi
JournalFitoterapia
Year2025

Key points

  • One new polyketide asperfuranone D (1), four new sesquiterpenes derivatives aspergillone C-F (2-5) and three known compounds (6-8) were successfully isolated from Aspergillus nidulans LZ8, a fungicolous fungi from the macrofungal Ganoderma lingzhi
  • The structures of these compounds were elucidated by extensive spectroscopic analyses including ultraviolet-visible spectroscopy (UV), mass spectrometry (MS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) calculation
  • In addition, the anti-inflammatory activities of the new compounds were evaluated using LPS-induced RAW 264.7 cells
  • The results revealed that compound 5 showed moderate nitric oxide (NO) inhibitory activity with the IC 50 value of 13.19 ± 1.05 μM, while the IC 50 value of the positive control L-NMMA was 41.88 ± 0.91 μM

Metadata-grounded summary

Citation abstract

One new polyketide asperfuranone D (1), four new sesquiterpenes derivatives aspergillone C-F (2-5) and three known compounds (6-8) were successfully isolated from Aspergillus nidulans LZ8, a fungicolous fungi from the macrofungal Ganoderma lingzhi. The structures of these compounds were elucidated by extensive spectroscopic analyses including ultraviolet-visible spectroscopy (UV), mass spectrometry (MS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) calculation. In addition, the anti-inflammatory activities of the new compounds were evaluated using LPS-induced RAW 264.7 cells. The results revealed that compound 5 showed moderate nitric oxide (NO) inhibitory activity with the IC 50 value of 13.19 ± 1.05 μM, while the IC 50 value of the positive control L-NMMA was 41.88 ± 0.91 μM.

Citation

Zhang H, Zhou Z, Yang M, Li S, Liu X, Jin L, et al. (2025). One new polyketide and four new sesquiterpenes derivatives from the fungicolous fungi aspergillus nidulans LZ8 of Ganoderma lingzhi. Fitoterapia https://doi.org/10.1016/j.fitote.2024.106339 PMID: 39657866

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