Six new metabolites from Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and their anti-inflammatory activities.

Ganoderma lucidum

OncologyImmune supportMetabolic healthLiver support

SpeciesReishi, Lingzhi

JournalFitoterapia

Year2025

Key points

Six undescribed trichophthalides A-F (1-6) and a known phthalide derivative (7) were isolated from Ganoderma lucidum-derived endophytic Trichoderma sp
Among them, meroterpenoids 1, 3, 4, 6, and 7 possessed an independent isoprenyl unit with varying degrees of oxidation
The structures and absolute configurations of these substances were elucidated on the basis of spectroscopic data, ECD and DP4+ calculations
Finally, compounds 1, 5, and 7 exhibited relatively weak abilities to inhibit the production of NO in LPS-stimulated RAW 264.7cells at a concentration of 60 μM

Metadata-grounded summary

Citation abstract

Six undescribed trichophthalides A-F (1-6) and a known phthalide derivative (7) were isolated from Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02. Among them, meroterpenoids 1, 3, 4, 6, and 7 possessed an independent isoprenyl unit with varying degrees of oxidation. The structures and absolute configurations of these substances were elucidated on the basis of spectroscopic data, ECD and DP4+ calculations. Finally, compounds 1, 5, and 7 exhibited relatively weak abilities to inhibit the production of NO in LPS-stimulated RAW 264.7cells at a concentration of 60 μM.

Citation

Qiu XH, Cheng X, Luo Q, Ma Y (2025). Six new metabolites from Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and their anti-inflammatory activities. Fitoterapia https://doi.org/10.1016/j.fitote.2025.106439 PMID: 39938656

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