Triterpenoids with inhibitory effects on lipid accumulation from Ganoderma lucidum.

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Citation abstract

Eight undescribed lanostane-type triterpenes (1-8) and twenty-seven known analogues (9-35) were isolated from the fruiting bodies of cultivated Ganoderma lucidum. The chemical structures of these compounds were elucidated using a combination of spectroscopic techniques. Ganosinenic acid D (1) and ganosinenic acid E (2) were identified as rare pentacyclic triterpenoids with an unusual four-membered carbon ring motif. The inhibitory effects of all compounds on lipid accumulation were evaluated in oleic acid (OA)-induced HepG2 cells. Among the tested compounds, ganolucidic acid G (7), lucidenic acid N (9), methyl lucidenate M (29) showed moderate inhibitory effects. Furthermore, lucidenic acid N inhibited lipid accumulation in a dose-dependent manner. The structure-activity relationship analysis revealed enhanced efficacy in side chain-degraded C 27 nor-triterpenoids compared to C 24 and C 30 analogs.