Reishi, Lingzhi · 2025 · Journal Article
High relevanceTrichodermanols A-C, three new metabolites from the Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and their anti-inflammatory activity.
Ganoderma lucidum
Key points
- Trichodermanols A-C (1-3), an uncommon nor-steroid (1) and two novel 5/7 ring system sesquiterpenes (2 and 3), along with two known compounds identified as (1S,7R,10S,11R)-3-oxoguai-4-ene-11,12-diol (4) and cyclo-((S)-Pro-(R)-Leu) (5), were isolated and elucidated from a Ganoderma lucidum-derived endophytic fungus Trichoderma sp
- Their chemical structures were elucidated on the basis of spectroscopic data and ECD and DP4 + calculations
- The biological activity of new isolates 1-3 was evaluated in LPS-stimulated RAW 264.7 cells
- The results revealed that trichodermanol A (1) exhibited potential anti-inflammatory activity
Metadata-grounded summary
Citation abstract
Trichodermanols A-C (1-3), an uncommon nor-steroid (1) and two novel 5/7 ring system sesquiterpenes (2 and 3), along with two known compounds identified as (1S,7R,10S,11R)-3-oxoguai-4-ene-11,12-diol (4) and cyclo-((S)-Pro-(R)-Leu) (5), were isolated and elucidated from a Ganoderma lucidum-derived endophytic fungus Trichoderma sp. GLQ02. Their chemical structures were elucidated on the basis of spectroscopic data and ECD and DP4 + calculations. The biological activity of new isolates 1-3 was evaluated in LPS-stimulated RAW 264.7 cells. The results revealed that trichodermanol A (1) exhibited potential anti-inflammatory activity.
Citation
Wu PP, Qiu XH, Yu HJ, Li LJ, Cheng X, Chen YP, et al. (2025). Trichodermanols A-C, three new metabolites from the Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and their anti-inflammatory activity. Fitoterapia https://doi.org/10.1016/j.fitote.2025.106657 PMID: 40472977
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