Triterpenoids from the edible mushroom Inonotus obliquus attenuates cognitive impairment in vitro and in vivo.

Inonotus obliquus

Cognition & nervesMetabolic healthSkin & hydration

SpeciesChaga

JournalFitoterapia

Year2025

Key points

Inonotus obliquus is an edible and medicinal mushroom which is used to multiple products
In this study, 8 secondary metabolites (1-8) were identified from the edible mushroom I. obliquus through nuclear magnetic resonance spectroscopy (NMR) data analysis
All metabolites were evaluated for anti-inflammatory activities in LPS-induced BV-2 microglial cells with the IC 50 values of 8.47-25.53 μM. Among these, compound 1 showed notably reduced NO generation, restrained COX-2, iNOS, IL-1β, IL-6 and TNF-α mRNA levels expression
Concurrently, the neuroprotective potential of compound 1 was preliminarily evaluated in a scopolamine (SCOP)-induced mice model
Behavioral assays revealed that supplementation with 1 markedly ameliorated cognitive impairment, and significantly suppressed the mRNA expression of neurotrophic factor, including NGF and BDNF. In conclusion, I. obliquus and compound 1 hold promise as natural therapeutic agents for improving cognitive function and related aspects of brain health

Metadata-grounded summary

Citation abstract

Inonotus obliquus is an edible and medicinal mushroom which is used to multiple products. In this study, 8 secondary metabolites (1-8) were identified from the edible mushroom I. obliquus through nuclear magnetic resonance spectroscopy (NMR) data analysis. All metabolites were evaluated for anti-inflammatory activities in LPS-induced BV-2 microglial cells with the IC 50 values of 8.47-25.53 μM. Among these, compound 1 showed notably reduced NO generation, restrained COX-2, iNOS, IL-1β, IL-6 and TNF-α mRNA levels expression. Concurrently, the neuroprotective potential of compound 1 was preliminarily evaluated in a scopolamine (SCOP)-induced mice model. Behavioral assays revealed that supplementation with 1 markedly ameliorated cognitive impairment, and significantly suppressed the mRNA expression of neurotrophic factor, including NGF and BDNF. In conclusion, I. obliquus and compound 1 hold promise as natural therapeutic agents for improving cognitive function and related aspects of brain health.

Citation

Kou RW, Bai GY, Yang XY, Liu GS, He YQ, Gao JM, et al. (2025). Triterpenoids from the edible mushroom Inonotus obliquus attenuates cognitive impairment in vitro and in vivo. Fitoterapia https://doi.org/10.1016/j.fitote.2025.106865 PMID: 40935198

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