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King Oyster, Eryngii · 2018 · Journal Article

High relevance

Antioxidation, anti-hyperglycaemia and renoprotective effects of extracellular polysaccharides from Pleurotus eryngii SI-04.

Pleurotus eryngii

Immune supportMetabolic health
SpeciesKing Oyster, Eryngii
JournalInternational journal of biological macromolecules
Year2018

Key points

  • The present study was designed to investigate the anti-hyperglycaemia, hypolipidemia and renoprotective effects of two extracellular polysaccharides (EPS) from the broth of Pleurotus eryngii SI-04 (EPS1 and EPS2) in mice with streptozotocin (STZ)-induced diabetic nephropathy (DN)
  • The results showed that both EPS1 and EPS2 exhibited potential anti-DN effects, including significantly decreasing GLU levels; suppressing ALB, BUN, CRE and UA levels; reducing serum lipid (TC, TG, VLDL-C and LDL-C) levels; improving renal antioxidant status (GSH-Px, SOD, CAT and MDA); and attenuating pathological nephropathy damage
  • These results demonstrated that both EPS1 and EPS2 exhibited potential antioxidant, anti-hyperglycaemic, and renoprotective effects against STZ-induced DN, indicating that P. eryngii SI-04 could be used as a functional food and natural drug
  • In addition, the monosaccharide compositions and bond types of these two polysaccharides were analysed

From the paper

Abstract

The present study was designed to investigate the anti-hyperglycaemia, hypolipidemia and renoprotective effects of two extracellular polysaccharides (EPS) from the broth of Pleurotus eryngii SI-04 (EPS1 and EPS2) in mice with streptozotocin (STZ)-induced diabetic nephropathy (DN). The results showed that both EPS1 and EPS2 exhibited potential anti-DN effects, including significantly decreasing GLU levels; suppressing ALB, BUN, CRE and UA levels; reducing serum lipid (TC, TG, VLDL-C and LDL-C) levels; improving renal antioxidant status (GSH-Px, SOD, CAT and MDA); and attenuating pathological nephropathy damage. These results demonstrated that both EPS1 and EPS2 exhibited potential antioxidant, anti-hyperglycaemic, and renoprotective effects against STZ-induced DN, indicating that P. eryngii SI-04 could be used as a functional food and natural drug. In addition, the monosaccharide compositions and bond types of these two polysaccharides were analysed.

Citation

Zhang C, Zhang L, Liu H, Zhang J, Hu C, Jia L (2018). Antioxidation, anti-hyperglycaemia and renoprotective effects of extracellular polysaccharides from Pleurotus eryngii SI-04. International journal of biological macromolecules https://doi.org/10.1016/j.ijbiomac.2018.01.009 PMID: 29309869

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