A novel Hericium erinaceus polysaccharide: Structural characterization and prevention of H2O2-induced oxidative damage in GES-1 cells.

Hericium erinaceus

Immune supportCognition & nerves

SpeciesLion's Mane, Yamabushitake

JournalInternational journal of biological macromolecules

Year2020

Key points

In this paper, the structural characteristics and bioactivity of a novel polysaccharide from H. erinaceus (HEP N ) were investigated, wherein, physico-chemical characterization demonstrated that HEP N with an average molecular weight of 12.713 kDa was composed of mannose (5.13%), glucose (43.02%), and galactose (51.85%)
The models in vitro for preventing oxidative damage of human gastric epithelium (GES-1) cells were established and used to investigate the preventive effects of HEP N from oxidative damage
It was found that HEP N could significantly prevent GES-1 cells against H 2 O 2 -induced oxidative damage by promoting cell proliferation, inhibiting cell necrosis, reducing ROS levels, regulating mitochondrial membrane potential and maintaining mitochondrial membrane permeability
These results indicated HEP N can effectively prevent gastric cell damage in vitro and suggested the potential application of HEP N as bioactive ingredient for healthy foods

Metadata-grounded summary

Citation abstract

In this paper, the structural characteristics and bioactivity of a novel polysaccharide from H. erinaceus (HEP N ) were investigated, wherein, physico-chemical characterization demonstrated that HEP N with an average molecular weight of 12.713 kDa was composed of mannose (5.13%), glucose (43.02%), and galactose (51.85%). The models in vitro for preventing oxidative damage of human gastric epithelium (GES-1) cells were established and used to investigate the preventive effects of HEP N from oxidative damage. It was found that HEP N could significantly prevent GES-1 cells against H 2 O 2 -induced oxidative damage by promoting cell proliferation, inhibiting cell necrosis, reducing ROS levels, regulating mitochondrial membrane potential and maintaining mitochondrial membrane permeability. These results indicated HEP N can effectively prevent gastric cell damage in vitro and suggested the potential application of HEP N as bioactive ingredient for healthy foods.

Citation

Liao B, Zhou C, Liu T, Dai Y, Huang H (2020). A novel Hericium erinaceus polysaccharide: Structural characterization and prevention of H2O2-induced oxidative damage in GES-1 cells. International journal of biological macromolecules https://doi.org/10.1016/j.ijbiomac.2019.11.027 PMID: 31759012

Open citation