Chemical analysis of Agaricus blazei polysaccharides and effect of the polysaccharides on IL-1beta mRNA expression in skin of burn wound-treated rats.

Agaricus blazei

Immune supportSkin & hydration

SpeciesAlmond Mushroom, ABM

JournalInternational journal of biological macromolecules

Year2010

Key points

Agaricus blazei polysaccharides were analyzed by GC-MS. Results indicated that the polysaccharides contained glucose (93.87%), mannose (3.54%), and arabinose (2.25%)
The compositional analysis was completed by the methylation data
These data indicated that Agaricus blazei polysaccharides are glucans
Compared to model rats, rats fed with Agaricus blazei polysaccharides showed a decrease of ratio of IL-1beta/beta-actin and IL-1beta level in skin of burn wound
Recovery rate of wound skin increased with increasing dose of polysaccharides
The results indicated that Agaricus blazei polysaccharides could be useful in promote burn wound healing

Metadata-grounded summary

Citation abstract

Agaricus blazei polysaccharides were analyzed by GC-MS. Results indicated that the polysaccharides contained glucose (93.87%), mannose (3.54%), and arabinose (2.25%). The compositional analysis was completed by the methylation data. These data indicated that Agaricus blazei polysaccharides are glucans. Compared to model rats, rats fed with Agaricus blazei polysaccharides showed a decrease of ratio of IL-1beta/beta-actin and IL-1beta level in skin of burn wound. Recovery rate of wound skin increased with increasing dose of polysaccharides. The results indicated that Agaricus blazei polysaccharides could be useful in promote burn wound healing.

Citation

Sui Z, Yang R, Liu B, Gu T, Zhao Z, Shi D, et al. (2010). Chemical analysis of Agaricus blazei polysaccharides and effect of the polysaccharides on IL-1beta mRNA expression in skin of burn wound-treated rats. International journal of biological macromolecules https://doi.org/10.1016/j.ijbiomac.2010.05.006 PMID: 20471414

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