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Lion's Mane, Yamabushitake · 2021 · Journal Article

High relevance

Multi-walled carbon nanotube polysaccharide modified Hericium erinaceus polysaccharide as an adjuvant to extend immune responses.

Hericium erinaceus

Immune supportCognition & nerves
SpeciesLion's Mane, Yamabushitake
JournalInternational journal of biological macromolecules
Year2021

Key points

  • In recent years, the utilization of CS-MWCNT as targeted drug carriers has attracted considerable attention
  • Hericium erinaceus polysaccharide (HEP) has been reported as an immunostimulant to improve immune responses
  • This study was focussed on developing CS-MWCNT encapsulating HEP (CS-MWCNT-HEP)
  • Using in mice peritoneal macrophages, we found the immune response could be effectively regulated by CS-MWCNT-HEP, promoted the expression of the MHCII, CD86, F4/80 and gp38
  • Moreover, the mice immunized with CS-MWCNT-HEP nanoparticles significantly extended PCV 2 -specific IgG immune response and the levels of cytokines
  • The results demonstrated that CS-MWCNT-HEP may be a promising drug delivery system for immuno-enhancement

Metadata-grounded summary

Citation abstract

In recent years, the utilization of CS-MWCNT as targeted drug carriers has attracted considerable attention. Hericium erinaceus polysaccharide (HEP) has been reported as an immunostimulant to improve immune responses. This study was focussed on developing CS-MWCNT encapsulating HEP (CS-MWCNT-HEP). Using in mice peritoneal macrophages, we found the immune response could be effectively regulated by CS-MWCNT-HEP, promoted the expression of the MHCII, CD86, F4/80 and gp38. Moreover, the mice immunized with CS-MWCNT-HEP nanoparticles significantly extended PCV 2 -specific IgG immune response and the levels of cytokines. The results demonstrated that CS-MWCNT-HEP may be a promising drug delivery system for immuno-enhancement.

Citation

Ren Z, Luo Y, Meng Z, Zhang J, Yu R, Sun M, et al. (2021). Multi-walled carbon nanotube polysaccharide modified Hericium erinaceus polysaccharide as an adjuvant to extend immune responses. International journal of biological macromolecules https://doi.org/10.1016/j.ijbiomac.2021.03.180 PMID: 33798583

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