Mesima, Sanghwang · 2006 · Research Support, Non U.S. Gov'T
Medium relevanceAcidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion.
Phellinus linteus
Key points
- The acidic polysaccharide (PL) from Phellinus linteus is an immunostimulator that has therapeutic activity against cancers
- Here, we show that PL markedly inhibits melanoma cell metastasis in mice, and report that PL directly inhibits cancer cell adhesion to and invasion through the extracellular matrix, but that it has no direct effect on cancer cell growth
- In addition, we found that PL increased macrophage NO production
- These results suggest that PL has two antimetastatic functions, i.e., it acts as an immunopotentiator and as a direct inhibitor of cancer cell adhesion
Metadata-grounded summary
Citation abstract
The acidic polysaccharide (PL) from Phellinus linteus is an immunostimulator that has therapeutic activity against cancers. Here, we show that PL markedly inhibits melanoma cell metastasis in mice, and report that PL directly inhibits cancer cell adhesion to and invasion through the extracellular matrix, but that it has no direct effect on cancer cell growth. In addition, we found that PL increased macrophage NO production. These results suggest that PL has two antimetastatic functions, i.e., it acts as an immunopotentiator and as a direct inhibitor of cancer cell adhesion.
Citation
Han SB, Lee CW, Kang JS, Yoon YD, Lee KH, Lee K, et al. (2006). Acidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion. International immunopharmacology https://doi.org/10.1016/j.intimp.2005.10.003 PMID: 16504934
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