Elimination of carbamazepine by repeated treatment with laccase in the presence of 1-hydroxybenzotriazole.

Trametes versicolor

OncologyImmune support

SpeciesTurkey Tail, Yun Zhi

JournalJournal of hazardous materials

Year2010

Key points

Carbamazepine (CBZP) is used as an antiepileptic drug and is highly persistent
In this study, CBZP was treated with laccase from white rot fungus Trametes versicolor in the presence of a redox mediator 1-hydroxybenzotriazole (HBT)
A single treatment with laccase and HBT eliminated CBZP by about 22% after 24h, and repeated treatments with laccase and HBT, which were added to the reaction mixture every 8h, helped eliminate about 60% of CBZP after 48h
This suggests that repeated treatment is effective in eliminating CBZP. Mass spectrometric analyses demonstrated that two degradation products of CBZP, 10,11-dihydro-10,11-epoxycarbamazepine and 9(10H)-acridone, were formed via repeated treatment with laccase and HBT

Metadata-grounded summary

Citation abstract

Carbamazepine (CBZP) is used as an antiepileptic drug and is highly persistent. In this study, CBZP was treated with laccase from white rot fungus Trametes versicolor in the presence of a redox mediator 1-hydroxybenzotriazole (HBT). A single treatment with laccase and HBT eliminated CBZP by about 22% after 24h, and repeated treatments with laccase and HBT, which were added to the reaction mixture every 8h, helped eliminate about 60% of CBZP after 48h. This suggests that repeated treatment is effective in eliminating CBZP. Mass spectrometric analyses demonstrated that two degradation products of CBZP, 10,11-dihydro-10,11-epoxycarbamazepine and 9(10H)-acridone, were formed via repeated treatment with laccase and HBT.

Citation

Hata T, Shintate H, Kawai S, Okamura H, Nishida T (2010). Elimination of carbamazepine by repeated treatment with laccase in the presence of 1-hydroxybenzotriazole. Journal of hazardous materials https://doi.org/10.1016/j.jhazmat.2010.05.103 PMID: 20619797

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