The mechanism of LZ-8-mediated immune response in the mouse model of Parkinson's disease.

Ganoderma lucidum

Immune supportCognition & nerves

SpeciesReishi, Lingzhi

JournalJournal of neuroimmunology

Year2023

Key points

Parkinson's disease (PD) is associated with microscopic changes in the brain, particularly substantia nigra (SN)
Ganoderma lucidum immunoregulatory protein (rLZ-8) is might confer protective effects against PD. We developed a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced murine model of PD and determined the effects of rLZ-8 on molecular and cellular components of SN and whole brain tissue
The levels of SOD, GSH-Px, p-JAK2 and p-STAT3 in the brain tissue and SN were downregulated, while IL-6, IL-1β, and TNF-α and MDA were upregulated
These effects were significantly reversed upon treatment rLZ-8
In summary, oxidative stress and inflammatory response in PD can be alleviated using rLZ-8

From the paper

Abstract

Parkinson's disease (PD) is associated with microscopic changes in the brain, particularly substantia nigra (SN). Ganoderma lucidum immunoregulatory protein (rLZ-8) is might confer protective effects against PD. We developed a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced murine model of PD and determined the effects of rLZ-8 on molecular and cellular components of SN and whole brain tissue. The levels of SOD, GSH-Px, p-JAK2 and p-STAT3 in the brain tissue and SN were downregulated, while IL-6, IL-1β, and TNF-α and MDA were upregulated. These effects were significantly reversed upon treatment rLZ-8. In summary, oxidative stress and inflammatory response in PD can be alleviated using rLZ-8.

Citation

Cheng H, Wang J, Zhang Y, Tang Y, Zhu L, Tao Y, et al. (2023). The mechanism of LZ-8-mediated immune response in the mouse model of Parkinson's disease. Journal of neuroimmunology https://doi.org/10.1016/j.jneuroim.2023.578144 PMID: 37696167

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