New insights into the chemistry and anticancer activity of Ophiocordyceps xuefengensis.

Ophiocordyceps sinensis

OncologyEnergy & fatigueRespiratory

SpeciesCordyceps, Caterpillar Fungus

JournalJournal of pharmaceutical and biomedical analysis

Year2024

Key points

Ophiocordyceps xuefengensis (O. xuefengensis), the sister taxon of Ophiocordyceps sinensis (O. sinensis), is consumed as a "tonic food" due to its health benefits
However, little is known regarding the chemistry and bioactivity of O. xuefengensis
In this study, we characterized 80 indole-based alkaloids in the ethyl acetate fraction of O. xuefengensis by high performance liquid chromatography-quadrupole time of flight mass spectrometry (HPLC-Q-TOF-MS/MS), of which 54 indole-based alkaloids were identified as possibly new compounds
Furthermore, 29 of these compounds were established as potential anti-cancer compounds by ligand fishing combined with HPLC-Q-TOF-MS/MS. Moreover, molecular docking identified the NH- and OH- groups of these compounds as the key active groups
The present study has expanded the knowledge on the characteristic indole-based alkaloids and anti-cancer activity of O. xuefengensis

Metadata-grounded summary

Citation abstract

Ophiocordyceps xuefengensis (O. xuefengensis), the sister taxon of Ophiocordyceps sinensis (O. sinensis), is consumed as a "tonic food" due to its health benefits. However, little is known regarding the chemistry and bioactivity of O. xuefengensis. In this study, we characterized 80 indole-based alkaloids in the ethyl acetate fraction of O. xuefengensis by high performance liquid chromatography-quadrupole time of flight mass spectrometry (HPLC-Q-TOF-MS/MS), of which 54 indole-based alkaloids were identified as possibly new compounds. Furthermore, 29 of these compounds were established as potential anti-cancer compounds by ligand fishing combined with HPLC-Q-TOF-MS/MS. Moreover, molecular docking identified the NH- and OH- groups of these compounds as the key active groups. The present study has expanded the knowledge on the characteristic indole-based alkaloids and anti-cancer activity of O. xuefengensis.

Citation

Qin Y, Zhou RR, Liu H, Shi SY, Zhang SH (2024). New insights into the chemistry and anticancer activity of Ophiocordyceps xuefengensis. Journal of pharmaceutical and biomedical analysis https://doi.org/10.1016/j.jpba.2024.116345 PMID: 38986348

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