Shiitake, Hua Gu · 2023 · Research Support, Non U.S. Gov'T
Low relevance"Eritadenine as a regulator of anxiety Disorders: An experimental and docking Approach".
Lentinula edodes
Key points
- Uncertainty persists regarding the specific chemical causal factors and their corresponding behavioral effects in anxiety disorders
- Commonly employed first-line treatments for anxiety target G protein-coupled receptors (GPCRs), including inhibitors of monoaminergic systems
- Alternatively, emerging natural bioactive strategies offer potential for mitigating adverse effects
- Recent investigations have implicated adenosine in anxiety-triggering mechanisms, while eritadenine, an adenosine analog derived from Shiitake mushroom, has displayed promising attributes
- This study explores eritadenine's potential as a bioactive substance for anxiety disorders in mice, employing behavioral tests, pentobarbital-sleep induction, and molecular docking
- Our findings suggest that eritadenine may modulate locomotor functions mediated by adenosine receptors, with a stronger affinity for binding to A 2A AR over A 1 AR, thus eliciting these effects
Metadata-grounded summary
Citation abstract
Uncertainty persists regarding the specific chemical causal factors and their corresponding behavioral effects in anxiety disorders. Commonly employed first-line treatments for anxiety target G protein-coupled receptors (GPCRs), including inhibitors of monoaminergic systems. Alternatively, emerging natural bioactive strategies offer potential for mitigating adverse effects. Recent investigations have implicated adenosine in anxiety-triggering mechanisms, while eritadenine, an adenosine analog derived from Shiitake mushroom, has displayed promising attributes. This study explores eritadenine's potential as a bioactive substance for anxiety disorders in mice, employing behavioral tests, pentobarbital-sleep induction, and molecular docking. Behavioral test results reveal a pronounced anxiolytic and sedative-hypnotic pharmacological effect of eritadenine. Our findings suggest that eritadenine may modulate locomotor functions mediated by adenosine receptors, with a stronger affinity for binding to A 2A AR over A 1 AR, thus eliciting these effects.
Citation
Gutiérrez-Rodelo C, Ochoa-López A, Luis Balderas-López J, Reyes-Ramírez A, Millán-Pacheco C, Favela-Rosales F, et al. (2023). "Eritadenine as a regulator of anxiety Disorders: An experimental and docking Approach". Neuroscience letters https://doi.org/10.1016/j.neulet.2023.137413 PMID: 37541318
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