Spiroganodermaines A-G from Ganoderma species and their activities against insulin resistance and renal fibrosis.

Ganoderma lucidum

OncologyImmune supportMetabolic healthLiver support

SpeciesReishi, Lingzhi

JournalPhytochemistry

Year2022

Key points

Ganoderma mushrooms are a renowned Chinese medicine and functional food used worldwide
Seven undescribed spiro Ganoderma meroterpenoids spiroganodermaines A-G were isolated from Ganoderma species
Their structures were characterized by using spectroscopic, computational and X-ray diffraction methods
Biological studies showed that (+)-spiroganodermaine G significantly activates glucose uptake and IRS1 phosphorylation in insulin resistance C2C12 cells
Furthermore, (-)-spiroganodermaine G inhibits the expressions of fibronectin and α-SMA in TGF-β1 induced NRK-52E cells
These findings demonstrate the potential of Ganoderma meroterpenoids as medicines and dietary supplements

Metadata-grounded summary

Citation abstract

Ganoderma mushrooms are a renowned Chinese medicine and functional food used worldwide. Seven undescribed spiro Ganoderma meroterpenoids spiroganodermaines A-G were isolated from Ganoderma species. Their structures were characterized by using spectroscopic, computational and X-ray diffraction methods. Biological studies showed that (+)-spiroganodermaine G significantly activates glucose uptake and IRS1 phosphorylation in insulin resistance C2C12 cells. Furthermore, (-)-spiroganodermaine G inhibits the expressions of fibronectin and α-SMA in TGF-β1 induced NRK-52E cells. These findings demonstrate the potential of Ganoderma meroterpenoids as medicines and dietary supplements.

Citation

Zhang JJ, Wang DW, Peng YL, Cai D, Cheng YX (2022). Spiroganodermaines A-G from Ganoderma species and their activities against insulin resistance and renal fibrosis. Phytochemistry https://doi.org/10.1016/j.phytochem.2022.113324 PMID: 35931232

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