Five undescribed cyclopeptides from Cordyceps militaris.

Ophiocordyceps sinensis

Energy & fatigueRespiratory

SpeciesCordyceps, Caterpillar Fungus

JournalPhytochemistry

Year2024

Key points

Ustiloxins I-M (1-5), five undescribed cyclopeptides bearing a 15-membered macrocyclic skeleton, were isolated from Cordyceps militaris
The structures of 1 and 5 were identified by spectroscopic and crystallographic methods, whereas the structures of 2-4 were assigned by spectroscopic and computational approaches
Biological evaluation of all the compounds toward human triple-negative breast cancer cells revealed that compounds 4 and 5 are toxic with IC 50 values of 64.29 μM and 28.89 μM, respectively

Metadata-grounded summary

Citation abstract

Ustiloxins I-M (1-5), five undescribed cyclopeptides bearing a 15-membered macrocyclic skeleton, were isolated from Cordyceps militaris. The structures of 1 and 5 were identified by spectroscopic and crystallographic methods, whereas the structures of 2-4 were assigned by spectroscopic and computational approaches. Biological evaluation of all the compounds toward human triple-negative breast cancer cells revealed that compounds 4 and 5 are toxic with IC 50 values of 64.29 μM and 28.89 μM, respectively.

Citation

Yang W, Fu C, Hu BY, Yan YM, Cheng YX (2024). Five undescribed cyclopeptides from Cordyceps militaris. Phytochemistry https://doi.org/10.1016/j.phytochem.2024.114074 PMID: 38604324

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