Baoslingzhines Q-X: Structurally previously undescribed trace phenolic meroterpenoids from Ganoderma lucidum and their biological activities toward renal fibrosis and cytotoxicity.

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Citation abstract

Eight previously undescribed phenolic meroterpenoids baoslingzhines Q-X (1-8) including three enantiomeric (±)-baoslingzhines Q-S (1-3) harboring a 2-methylbenzofuran moiety, two trinormeroterpenoids baoslingzhines T and U (4 and 5) containing a 5-methylbenzyl motif as a connection point with another ring, an alkaloid baoslingzhine V (6) possessing 3-methylquinoline, were purified from Ganoderma lucidum. Their planar structures and the absolute configurations were elucidated based on spectroscopic methods and experimental electronic circular dichroism calculations. Compound 6 was capable of diminishing the expression of fibronectin and α-SMA, while compound 8 might dose-dependently attenuate fibronectin and collagen I expression. Besides, inhibition of cell viability of compounds 4-6 toward five human cancer cell lines were observed.