Seven undescribed metabolites from Ganoderma lucidum-derived endophytic Talaromyces sp. GLQ04 and their anti-DLBCL (diffuse large B-cell lymphoma) activities.

Ganoderma lucidum

Oncology

SpeciesReishi, Lingzhi

JournalPhytochemistry

Year2026

Key points

Seven undescribed metabolites and four known compounds were isolated from a Ganoderma lucidum-derived endophytic fungus Talaromyces sp
Their structures including absolute configurations were assigned by using spectroscopic data and ECD calculations
Among them, (±)-3 and (±)-5 were obtained as a mixture
Chiral HPLC was employed to separate two pairs of enantiomers (+)-3 and (-)-3, and (+)-5 and (-)-5
The cytotoxic bioactivities of compounds 1-9 against DLBCL (diffuse large B-cell lymphoma) cells were evaluated
The results showed that compounds 6, 7 and 8 exhibited inhibitory activities against DLBCL cells, with IC50 values of 10.68 μM, 61.04 μM and 17.12 μM, respectively

From the paper

Abstract

Seven undescribed metabolites and four known compounds were isolated from a Ganoderma lucidum-derived endophytic fungus Talaromyces sp. GLQ04. Their structures including absolute configurations were assigned by using spectroscopic data and ECD calculations. Among them, (±)-3 and (±)-5 were obtained as a mixture. Chiral HPLC was employed to separate two pairs of enantiomers (+)-3 and (-)-3, and (+)-5 and (-)-5. The cytotoxic bioactivities of compounds 1-9 against DLBCL (diffuse large B-cell lymphoma) cells were evaluated. The results showed that compounds 6, 7 and 8 exhibited inhibitory activities against DLBCL cells, with IC50 values of 10.68 μM, 61.04 μM and 17.12 μM, respectively.

Citation

Liu S, Sun H, Li PT, Li PS, Cheng X, Wang F, et al. (2026). Seven undescribed metabolites from Ganoderma lucidum-derived endophytic Talaromyces sp. GLQ04 and their anti-DLBCL (diffuse large B-cell lymphoma) activities. Phytochemistry https://doi.org/10.1016/j.phytochem.2026.114816 PMID: 41672361

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