Lucidumones L-P: Meroterpenoids from Ganoderma lucidum and their inhibitory effect on triple negative breast cancer.

Ganoderma lucidum

OncologyImmune supportMetabolic healthLiver support

SpeciesReishi, Lingzhi

JournalPhytochemistry

Year2026

Key points

Meroterpenoids in Ganoderma mushrooms have attracted attention in recent years
In this effort, lucidumones L-P (1-5), five undescribed meroterpenoids, including four without chirality (1-4) and a pair of enantiomers (5), were isolated from G. lucidum
Their structures were elucidated using spectroscopic and computational methods
Compound 1 was structurally characterized as a decarbonized dimeric meroterpenoid
Compounds 2 and 3 possess significant inhibitory effects on the cell migration of MDA-MB-231 cells, and compound 2 inhibits the cell migration dose-dependently

Metadata-grounded summary

Citation abstract

Meroterpenoids in Ganoderma mushrooms have attracted attention in recent years. In this effort, lucidumones L-P (1-5), five undescribed meroterpenoids, including four without chirality (1-4) and a pair of enantiomers (5), were isolated from G. lucidum. Their structures were elucidated using spectroscopic and computational methods. Compound 1 was structurally characterized as a decarbonized dimeric meroterpenoid. Compounds 2 and 3 possess significant inhibitory effects on the cell migration of MDA-MB-231 cells, and compound 2 inhibits the cell migration dose-dependently.

Citation

Zhang JJ, Wu ZH, Yuan YN, Cai D, Liu JW, Zhou H, et al. (2026). Lucidumones L-P: Meroterpenoids from Ganoderma lucidum and their inhibitory effect on triple negative breast cancer. Phytochemistry https://doi.org/10.1016/j.phytochem.2026.114927 PMID: 42002126

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