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Reishi, Lingzhi · 2026 · Journal Article

High relevance

Bsglucidines A-I: Eight previously undescribed meroterpenoids and a des-D-steroid from Ganoderma lucidum with anti-renal fibrotic activities.

Ganoderma lucidum

OncologyImmune supportMetabolic healthLiver support
SpeciesReishi, Lingzhi
JournalPhytochemistry
Year2026

Key points

  • Eight previously undescribed Ganoderma meroterpenoids (GMs) including four enantiomeric bsglucidines A-D (1 and 3-5), two 6/6/6 and two 6/5/6 scaffold meroterpenoids bsglucidines F-I (7-10), an ergosteroid bsglucidine E (6), and one known GM cochlearol O (2) were isolated from the fruiting bodies of Ganoderma lucidum (Leyss.ex Fr.) Karst
  • These structures and their stereochemical features were identified using spectroscopic data and ECD calculations
  • The anti-renal fibrotic activities of compounds 1-10 were evaluated using CCK-8 assays and Western blot analysis
  • Among them, compounds (+)-4 and 6 show notable inhibitory effects on fibrotic responses in NRK-52E rat renal tubular epithelial cells as well as NRK-49F rat renal fibroblasts

Metadata-grounded summary

Citation abstract

Eight previously undescribed Ganoderma meroterpenoids (GMs) including four enantiomeric bsglucidines A-D (1 and 3-5), two 6/6/6 and two 6/5/6 scaffold meroterpenoids bsglucidines F-I (7-10), an ergosteroid bsglucidine E (6), and one known GM cochlearol O (2) were isolated from the fruiting bodies of Ganoderma lucidum (Leyss.ex Fr.) Karst. These structures and their stereochemical features were identified using spectroscopic data and ECD calculations. The anti-renal fibrotic activities of compounds 1-10 were evaluated using CCK-8 assays and Western blot analysis. Among them, compounds (+)-4 and 6 show notable inhibitory effects on fibrotic responses in NRK-52E rat renal tubular epithelial cells as well as NRK-49F rat renal fibroblasts.

Citation

Chen MY, Xu YS, Liu YY, Cheng YX (2026). Bsglucidines A-I: Eight previously undescribed meroterpenoids and a des-D-steroid from Ganoderma lucidum with anti-renal fibrotic activities. Phytochemistry https://doi.org/10.1016/j.phytochem.2026.114959 PMID: 42142826

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