Back to search

Enoki, Winter Mushroom · 1997 · Research Support, Non U.S. Gov'T

Medium relevance

The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes.

Flammulina velutipes

OncologyImmune support
SpeciesEnoki, Winter Mushroom
JournalImmunopharmacology
Year1997

Key points

  • Alkaline-soluble antitumor polysaccharide was prepared from the cell wall of the mushroom Flammulina velutipes
  • The backbones) of the polysaccharide is mainly composed of beta-(1-->3)-D-linked glucose and its molecular weight was estimated to be about 200 kD. The polysaccharide was found to be non-toxic by brine shrimp assay
  • When injected into mice intraperitoneally, the polysaccharide triggered proliferation of splenic lymphocytes and also vascular dilation and hemorrhage (VDH) response
  • The polysaccharide exhibited potent anti-tumor activity against sarcoma SC-180 in vivo but not in vitro

Metadata-grounded summary

Citation abstract

Alkaline-soluble antitumor polysaccharide was prepared from the cell wall of the mushroom Flammulina velutipes. The backbones) of the polysaccharide is mainly composed of beta-(1-->3)-D-linked glucose and its molecular weight was estimated to be about 200 kD. The polysaccharide was found to be non-toxic by brine shrimp assay. When injected into mice intraperitoneally, the polysaccharide triggered proliferation of splenic lymphocytes and also vascular dilation and hemorrhage (VDH) response. The polysaccharide exhibited potent anti-tumor activity against sarcoma SC-180 in vivo but not in vitro.

Citation

Leung MY, Fung KP, Choy YM (1997). The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from Flammulina velutipes. Immunopharmacology https://doi.org/10.1016/s0162-3109(96)00157-9 PMID: 9043939

Open citation