Maitake, Hen of the Woods · 2003 · Journal Article
Medium relevanceRelationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB/c tumor-bearing mice.
Grifola frondosa
Key points
- Dendritic cells (DCs) are known to not only induce the activation of T cells, but are also associated with the differentiation of T cells
- The D-fraction, a beta-glucan extracted from maitake (Grifola frondosa) which expresses anti-tumor effects by establishing a helper (Th)-1 dominance in BALB/c mice, enhanced IL-12p70 production by DCs, when the ratio of CD8alpha(+) DCs to CD8alpha(-) DCs increased
- In addition, examination of the tumor rejection effect of D-fraction-stimulated DCs loaded with tumor antigen revealed that tumor growth is inhibited completely by activating CD4(+) T cells and CD8(+) T cells
Metadata-grounded summary
Citation abstract
Dendritic cells (DCs) are known to not only induce the activation of T cells, but are also associated with the differentiation of T cells. The D-fraction, a beta-glucan extracted from maitake (Grifola frondosa) which expresses anti-tumor effects by establishing a helper (Th)-1 dominance in BALB/c mice, enhanced IL-12p70 production by DCs, when the ratio of CD8alpha(+) DCs to CD8alpha(-) DCs increased. In addition, examination of the tumor rejection effect of D-fraction-stimulated DCs loaded with tumor antigen revealed that tumor growth is inhibited completely by activating CD4(+) T cells and CD8(+) T cells.
Citation
Harada N, Kodama N, Nanba H (2003). Relationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB/c tumor-bearing mice. Cancer letters https://doi.org/10.1016/s0304-3835(02)00716-4 PMID: 12668282
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