Reishi, Lingzhi · 2023 · Research Support, Non U.S. Gov'T
High relevanceOne-Pot Assembly of the Highly Branched Tetradecasaccharide from Ganoderma lucidum Glycan GLSWA-1 with Immune-Enhancing Activities.
Ganoderma lucidum
Key points
- The highly branched tetradecasaccharide repeating unit and shorter sequences of GLSWA-1 with immune-enhancing activities from Ganoderma lucidum have been prepared via a one-pot glycan assembly strategy
- The synthetic route features (1) orthogonal one-pot glycosylation on the basis of PVB glycosylation to streamline glycan synthesis avoiding such issues as aglycone transfer, (2) one-pot assembly of oligosaccharides with up to four different glycosyl linkages, and (3) modular and convergent [4+5+5] one-pot assembly of the highly branched tetradecasaccharide
Metadata-grounded summary
Citation abstract
The highly branched tetradecasaccharide repeating unit and shorter sequences of GLSWA-1 with immune-enhancing activities from Ganoderma lucidum have been prepared via a one-pot glycan assembly strategy. The synthetic route features (1) orthogonal one-pot glycosylation on the basis of PVB glycosylation to streamline glycan synthesis avoiding such issues as aglycone transfer, (2) one-pot assembly of oligosaccharides with up to four different glycosyl linkages, and (3) modular and convergent [4+5+5] one-pot assembly of the highly branched tetradecasaccharide.
Citation
Chen Z, Xiao G (2023). One-Pot Assembly of the Highly Branched Tetradecasaccharide from Ganoderma lucidum Glycan GLSWA-1 with Immune-Enhancing Activities. Organic letters https://doi.org/10.1021/acs.orglett.3c02898 PMID: 37787430
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