Chaga · 2020 · Research Support, Non U.S. Gov'T
High relevanceSpiroinonotsuoxotriols A and B, Two Highly Rearranged Triterpenoids from Inonotus obliquus.
Inonotus obliquus
Key points
- Spiroinonotsuoxotriols A ( 1 ) and B ( 2 ), two highly rearranged pentacyclic triterpenoids featuring a novel 7(8 → 9)abeo-21,24-cyclo-lanostane skeleton, together with their proposed precursors 3 - 5, were isolated from the sclerotia of the white-rot fungus Inonotus obliquus
- Their structures including the absolute configurations were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction
- The biogenetic pathway of 1 and 2 was proposed
- Compounds 1 and 2 exhibited potent α-glucosidase inhibitory activity as compared with the positive control acarbose
Metadata-grounded summary
Citation abstract
Spiroinonotsuoxotriols A ( 1 ) and B ( 2 ), two highly rearranged pentacyclic triterpenoids featuring a novel 7(8 → 9)abeo-21,24-cyclo-lanostane skeleton, together with their proposed precursors 3 - 5, were isolated from the sclerotia of the white-rot fungus Inonotus obliquus. Their structures including the absolute configurations were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction. The biogenetic pathway of 1 and 2 was proposed. Compounds 1 and 2 exhibited potent α-glucosidase inhibitory activity as compared with the positive control acarbose.
Citation
Ying YM, Yu HF, Tong CP, Shan WG, Zhan ZJ (2020). Spiroinonotsuoxotriols A and B, Two Highly Rearranged Triterpenoids from Inonotus obliquus. Organic letters https://doi.org/10.1021/acs.orglett.0c00866 PMID: 32285675
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