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Cordyceps, Scarlet Club · 2022 · Research Support, Non U.S. Gov'T

High relevance

Total Synthesis of Cordyceps militaris Glycans via Stereoselective Orthogonal One-Pot Glycosylation and α-Glycosylation Strategies.

Cordyceps militaris

Energy & fatigue
SpeciesCordyceps, Scarlet Club
JournalOrganic letters
Year2022

Key points

  • Cordyceps militaris glycans with potent antioxidant activities have been efficiently and collectively synthesized
  • The synthetic approach features the following: (1) a stereoselective orthogonal one-pot glycosylation strategy for both 1,2- trans - and 1,2- cis -glycosidic linkages; (2) a merged reagent modulation and remote anchimeric assistance (RMRAA) α-glucosylation strategy; (3) DMF-modulated α-glucosylation; (4) convergent [3 + 4 + 6] orthogonal one-pot assembly of the target tridecasaccharide

Metadata-grounded summary

Citation abstract

Cordyceps militaris glycans with potent antioxidant activities have been efficiently and collectively synthesized. The synthetic approach features the following: (1) a stereoselective orthogonal one-pot glycosylation strategy for both 1,2- trans - and 1,2- cis -glycosidic linkages; (2) a merged reagent modulation and remote anchimeric assistance (RMRAA) α-glucosylation strategy; (3) DMF-modulated α-glucosylation; (4) convergent [3 + 4 + 6] orthogonal one-pot assembly of the target tridecasaccharide.

Citation

Ma Y, Jiang Q, Wang X, Xiao G (2022). Total Synthesis of Cordyceps militaris Glycans via Stereoselective Orthogonal One-Pot Glycosylation and α-Glycosylation Strategies. Organic letters https://doi.org/10.1021/acs.orglett.2c03081 PMID: 36286593

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