Cordyceps, Caterpillar Fungus · 2022 · Research Support, Non U.S. Gov'T
Medium relevanceTotal Synthesis of Cordyceps militaris Glycans via Stereoselective Orthogonal One-Pot Glycosylation and α-Glycosylation Strategies.
Ophiocordyceps sinensis
Key points
- Cordyceps militaris glycans with potent antioxidant activities have been efficiently and collectively synthesized
- The synthetic approach features the following: (1) a stereoselective orthogonal one-pot glycosylation strategy for both 1,2- trans - and 1,2- cis -glycosidic linkages; (2) a merged reagent modulation and remote anchimeric assistance (RMRAA) α-glucosylation strategy; (3) DMF-modulated α-glucosylation; (4) convergent [3 + 4 + 6] orthogonal one-pot assembly of the target tridecasaccharide
Metadata-grounded summary
Citation abstract
Cordyceps militaris glycans with potent antioxidant activities have been efficiently and collectively synthesized. The synthetic approach features the following: (1) a stereoselective orthogonal one-pot glycosylation strategy for both 1,2- trans - and 1,2- cis -glycosidic linkages; (2) a merged reagent modulation and remote anchimeric assistance (RMRAA) α-glucosylation strategy; (3) DMF-modulated α-glucosylation; (4) convergent [3 + 4 + 6] orthogonal one-pot assembly of the target tridecasaccharide.
Citation
Ma Y, Jiang Q, Wang X, Xiao G (2022). Total Synthesis of Cordyceps militaris Glycans via Stereoselective Orthogonal One-Pot Glycosylation and α-Glycosylation Strategies. Organic letters https://doi.org/10.1021/acs.orglett.2c03081 PMID: 36286593
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