Cordycicadins A-D, Antifeedant Polyketides from the Entomopathogenic Fungus Cordyceps cicadae JXCH1.

Cordyceps militaris

SpeciesCordyceps, Scarlet Club

JournalOrganic letters

Year2022

Key points

Cordycicadins A-D (1-4) are four novel polyketides that were isolated from the liquid fermentation of the insect-pathogenic fungus Cordyceps cicadae JXCH1
The structures were determined by a combination of spectroscopic analysis, single-crystal X-ray diffraction, and computational methods
Compounds 1, 3, and 4 harbor an unusual exocyclic enol ether bridge that connects the separated ring systems
Hypothetical biosynthetic pathways for 1-4 were proposed
Cordycicadins A (1) and B (2) showed antifeedant activity against silkworm larvae (Bombyx mori) with EC50 values of 65.4 and 57.0 μg/cm2, respectively

From the paper

Abstract

Cordycicadins A-D (1-4) are four novel polyketides that were isolated from the liquid fermentation of the insect-pathogenic fungus Cordyceps cicadae JXCH1. The structures were determined by a combination of spectroscopic analysis, single-crystal X-ray diffraction, and computational methods. Compounds 1, 3, and 4 harbor an unusual exocyclic enol ether bridge that connects the separated ring systems. Hypothetical biosynthetic pathways for 1-4 were proposed. Cordycicadins A (1) and B (2) showed antifeedant activity against silkworm larvae (Bombyx mori) with EC50 values of 65.4 and 57.0 μg/cm2, respectively.

Citation

Li X, Chen HP, Zhou L, Fan J, Awakawa T, Mori T, et al. (2022). Cordycicadins A-D, Antifeedant Polyketides from the Entomopathogenic Fungus Cordyceps cicadae JXCH1. Organic letters https://doi.org/10.1021/acs.orglett.2c03432 PMID: 36394522

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