Cordyceps, Caterpillar Fungus · 2022 · Research Support, Non U.S. Gov'T
Medium relevanceCordycicadins A-D, Antifeedant Polyketides from the Entomopathogenic Fungus Cordyceps cicadae JXCH1.
Ophiocordyceps sinensis
Key points
- Cordycicadins A-D ( 1 - 4 ) are four novel polyketides that were isolated from the liquid fermentation of the insect-pathogenic fungus Cordyceps cicadae JXCH1
- The structures were determined by a combination of spectroscopic analysis, single-crystal X-ray diffraction, and computational methods
- Compounds 1, 3, and 4 harbor an unusual exocyclic enol ether bridge that connects the separated ring systems
- Hypothetical biosynthetic pathways for 1 - 4 were proposed
- Cordycicadins A ( 1 ) and B ( 2 ) showed antifeedant activity against silkworm larvae ( Bombyx mori ) with EC 50 values of 65.4 and 57.0 μg/cm 2, respectively
Metadata-grounded summary
Citation abstract
Cordycicadins A-D ( 1 - 4 ) are four novel polyketides that were isolated from the liquid fermentation of the insect-pathogenic fungus Cordyceps cicadae JXCH1. The structures were determined by a combination of spectroscopic analysis, single-crystal X-ray diffraction, and computational methods. Compounds 1, 3, and 4 harbor an unusual exocyclic enol ether bridge that connects the separated ring systems. Hypothetical biosynthetic pathways for 1 - 4 were proposed. Cordycicadins A ( 1 ) and B ( 2 ) showed antifeedant activity against silkworm larvae ( Bombyx mori ) with EC 50 values of 65.4 and 57.0 μg/cm 2, respectively.
Citation
Li X, Chen HP, Zhou L, Fan J, Awakawa T, Mori T, et al. (2022). Cordycicadins A-D, Antifeedant Polyketides from the Entomopathogenic Fungus Cordyceps cicadae JXCH1. Organic letters https://doi.org/10.1021/acs.orglett.2c03432 PMID: 36394522
Open citation