Chizhiaroterpenoids A-C: Benzofused Rearranged Lanostane-Type Triterpenoids from Ganoderma lucidum.

Ganoderma lucidum

OncologyImmune supportMetabolic healthLiver support

SpeciesReishi, Lingzhi

JournalOrganic letters

Year2025

Key points

Chizhiaroterpenoids A-C ( 1 - 3 ), three unprecedented skeletal benzofused lanostane-type triterpenoids with unprecedented 6/6/6/6/6 ( 1 ), 6/6/6/6/7 ( 2 ), and 6/6/6/5/6 ( 3 ) ring systems, were isolated from Ganoderma lucidum
Their biosynthetic pathways were proposed. 1 and 3 suppressed lipopolysaccharide-induced inflammation in BV2 cells, restored BDNF levels, and alleviated depression-like behaviors in mice
Additionally, 2 and 3 inhibited cancer-associated fibroblast-mediated extracellular matrix remodeling by modulating laminin, suggesting potential anti-breast cancer effects

Metadata-grounded summary

Citation abstract

Chizhiaroterpenoids A-C ( 1 - 3 ), three unprecedented skeletal benzofused lanostane-type triterpenoids with unprecedented 6/6/6/6/6 ( 1 ), 6/6/6/6/7 ( 2 ), and 6/6/6/5/6 ( 3 ) ring systems, were isolated from Ganoderma lucidum. Their biosynthetic pathways were proposed. 1 and 3 suppressed lipopolysaccharide-induced inflammation in BV2 cells, restored BDNF levels, and alleviated depression-like behaviors in mice. Additionally, 2 and 3 inhibited cancer-associated fibroblast-mediated extracellular matrix remodeling by modulating laminin, suggesting potential anti-breast cancer effects.

Citation

Liu YY, Li WF, Xu YS, Liu XN, Fang F, Wang H, et al. (2025). Chizhiaroterpenoids A-C: Benzofused Rearranged Lanostane-Type Triterpenoids from Ganoderma lucidum. Organic letters https://doi.org/10.1021/acs.orglett.5c03142 PMID: 40903439

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