Lion's Mane, Yamabushitake · 2016 · Research Support, Non U.S. Gov'T
High relevanceErinacine S, a Rare Sesterterpene from the Mycelia of Hericium erinaceus.
Hericium erinaceus
Key points
- A new sesterterpene, erinacine S, and one cyathane diterpene xyloside, erinacine A, were isolated from the ethanol extract of the mycelia of Hericium erinaceus
- Their structures were elucidated by spectroscopic and X-ray analysis
- A 30-day oral course of erinacines A and S attenuated Aβ plaque burden in the brains of 5-month-old female APP/PS1 transgenic mice
- Moreover, erinacines A and S significantly increased the level of insulin-degrading enzyme in cerebral cortex
From the paper
Abstract
A new sesterterpene, erinacine S, and one cyathane diterpene xyloside, erinacine A, were isolated from the ethanol extract of the mycelia of Hericium erinaceus. Their structures were elucidated by spectroscopic and X-ray analysis. A 30-day oral course of erinacines A and S attenuated Aβ plaque burden in the brains of 5-month-old female APP/PS1 transgenic mice. Moreover, erinacines A and S significantly increased the level of insulin-degrading enzyme in cerebral cortex.
Citation
Chen CC, Tzeng TT, Chen CC, Ni CL, Lee LY, Chen WP, et al. (2016). Erinacine S, a Rare Sesterterpene from the Mycelia of Hericium erinaceus. Journal of natural products https://doi.org/10.1021/acs.jnatprod.5b00474 PMID: 26807743
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