Yellow Morel · 2002 · Research Support, U.S. Gov'T, Non P.H.S.
Medium relevanceIsolation of a galactomannan that enhances macrophage activation from the edible fungus Morchella esculenta.
Morchella esculenta
Key points
- The edible mushroom Morchella esculenta is among the most highly prized and morphologically recognizable fungi in the world
- We describe the isolation from a polar extract of M. esculenta carpophores of a high-molecular-weight galactomannan, about 1.0 million Da, that exhibits immunostimulatory activity
- At 3.0 microg/mL the galactomannan polysaccharide increased NF-kappa B directed luciferase expression in THP-1 human monocytic cells to levels 50% of those achieved by maximal activating concentration (10 microg/mL) of lipopolysaccharide
- This galactomannan comprises about 2.0% of the dry fungal material weight, and its glycosyl components include mannose (62.9%) and galactose (20.0%)
Metadata-grounded summary
Citation abstract
The edible mushroom Morchella esculenta is among the most highly prized and morphologically recognizable fungi in the world. We describe the isolation from a polar extract of M. esculenta carpophores of a high-molecular-weight galactomannan, about 1.0 million Da, that exhibits immunostimulatory activity. At 3.0 microg/mL the galactomannan polysaccharide increased NF-kappa B directed luciferase expression in THP-1 human monocytic cells to levels 50% of those achieved by maximal activating concentration (10 microg/mL) of lipopolysaccharide. This galactomannan comprises about 2.0% of the dry fungal material weight, and its glycosyl components include mannose (62.9%) and galactose (20.0%).
Citation
Duncan CJ, Pugh N, Pasco DS, Ross SA (2002). Isolation of a galactomannan that enhances macrophage activation from the edible fungus Morchella esculenta. Journal of agricultural and food chemistry https://doi.org/10.1021/jf020267c PMID: 12236698
Open citation