King Oyster, Eryngii · 2012 · Research Support, Non U.S. Gov'T
High relevanceEryngiolide A, a cytotoxic macrocyclic diterpenoid with an unusual cyclododecane core skeleton produced by the edible mushroom Pleurotus eryngii.
Pleurotus eryngii
Key points
- Eryngiolide A (1), the first member of C20 diterpenoids with the skeleton deriving from a cyclododecane core fused with two γ-lactone units, was isolated from the solid culture of the edible mushroom Pleurotus eryngii
- The structure of 1 was elucidated by extensive analysis of NMR spectra
- Compound 1 exhibited moderate cytotoxicity against two human cancer lines in vitro
Metadata-grounded summary
Citation abstract
Eryngiolide A (1), the first member of C20 diterpenoids with the skeleton deriving from a cyclododecane core fused with two γ-lactone units, was isolated from the solid culture of the edible mushroom Pleurotus eryngii. The structure of 1 was elucidated by extensive analysis of NMR spectra. Compound 1 exhibited moderate cytotoxicity against two human cancer lines in vitro.
Citation
Wang SJ, Li YX, Bao L, Han JJ, Yang XL, Li HR, et al. (2012). Eryngiolide A, a cytotoxic macrocyclic diterpenoid with an unusual cyclododecane core skeleton produced by the edible mushroom Pleurotus eryngii. Organic letters https://doi.org/10.1021/ol301519m PMID: 22769974
Open citation