Lion's Mane, Yamabushitake · 2018 · Journal Article
High relevanceThree new cyathane diterpenes with neurotrophic activity from the liquid cultures of Hericium erinaceus.
Hericium erinaceus
Key points
- Three new cyathane diterpenes erinacines T-V (1-3), and two known cyathane diterpenes erinacine A (4) and erinacine P (5) were isolated from the liquid cultures of Hericium erinaceus
- The structures of 1-3 were determined by extensive spectroscopic analysis
- All isolated compounds were evaluated for the cytotoxicity, and neurite-promoting activities using PC12 cell line
- Compounds 1-3, and 5 exhibited pronounced neurite outgrowth-promoting effects on PC12 cells in the range of 2.5-10 μM. Compound 4 showed weak cytotoxicity against PC12 cells with IC 50 of 73.7 μM
Metadata-grounded summary
Citation abstract
Three new cyathane diterpenes erinacines T-V (1-3), and two known cyathane diterpenes erinacine A (4) and erinacine P (5) were isolated from the liquid cultures of Hericium erinaceus. The structures of 1-3 were determined by extensive spectroscopic analysis. All isolated compounds were evaluated for the cytotoxicity, and neurite-promoting activities using PC12 cell line. Compounds 1-3, and 5 exhibited pronounced neurite outgrowth-promoting effects on PC12 cells in the range of 2.5-10 μM. Compound 4 showed weak cytotoxicity against PC12 cells with IC 50 of 73.7 μM.
Citation
Zhang Y, Liu L, Bao L, Yang Y, Ma K, Liu H (2018). Three new cyathane diterpenes with neurotrophic activity from the liquid cultures of Hericium erinaceus. The Journal of antibiotics https://doi.org/10.1038/s41429-018-0065-8 PMID: 29780164
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