Cordyceps, Caterpillar Fungus · 2023 · Research Support, Non U.S. Gov'T
Medium relevanceTwo new diketopiperazines from the Cordyceps fungus Samsoniella sp. XY4.
Ophiocordyceps sinensis
Key points
- Two new diketopiperazines, namely samsoniellain A (1) and samsoniellain B (2), together with two known compounds (3, 4) were isolated from Cordyceps fungus Samsoniella sp
- The planar structures of 1 and 2 were determined by HRESIMS, 1D and 2D NMR spectroscopy
- The absolute configurations of 1 and 2 were determined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra
- Results of antimicrobial activity indicated that compound 2 showed weak bacteriostatic activities against S. typhimurium χ 8956, H. influenza ATCC 10211, MRSA 2024 with the MIC values of 128, 256, and 256 μg ml -1, respectively
- This is the first report about secondary metabolites of Samsoniella sp
Metadata-grounded summary
Citation abstract
Two new diketopiperazines, namely samsoniellain A (1) and samsoniellain B (2), together with two known compounds (3, 4) were isolated from Cordyceps fungus Samsoniella sp. XY4. The planar structures of 1 and 2 were determined by HRESIMS, 1D and 2D NMR spectroscopy. The absolute configurations of 1 and 2 were determined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Results of antimicrobial activity indicated that compound 2 showed weak bacteriostatic activities against S. typhimurium χ 8956, H. influenza ATCC 10211, MRSA 2024 with the MIC values of 128, 256, and 256 μg ml -1, respectively. This is the first report about secondary metabolites of Samsoniella sp.
Citation
Zhang KT, Huang ZP, Xu XR, Li SH, Xu YX, Zhao Q, et al. (2023). Two new diketopiperazines from the Cordyceps fungus Samsoniella sp. XY4. The Journal of antibiotics https://doi.org/10.1038/s41429-023-00662-7 PMID: 37789127
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